Research

We are interested in the mechanisms of neuroinflammation and neurodegeneration in the brain. We use mouse models of disease and cultured brain cells to investigate how microglia become activated by inflammatory stimuli, and how such microglia can damage or protect neurons. We are particularly interested in the roles of microglial phagocytosis in neurodegeneration, as we have found that inflamed microglia can phagocytose (i.e. eat) live neurons and neuronal parts such as synapses. And so we are trying to find ways to prevent this.

Current research interests are:
(i) microglia,
(ii) phagocytosis, and
(iii) Neurodegeneration.

Microglia

Microglia are brain macrophages. We are trying to understand how microglia damage or protect neurons during neuroinflammation and brain pathologies, such as neurodegeneration. Want to know more?

Phagocytosis

Phagocytosis is the process by which cells eat extracellular material, including other cells.
We are trying to understand: the signals that regulate phagocytosis of cells, and its roles in physiology and disease. Want to know more?

Neurodegeneration

Neurodegeneration is the progressive damage and death of neurons during neurodegenerative diseases, such as Alzheimer’s Disease. We are trying to understand the roles of microglia, phagocytosis and cell death in neurodegeneration. Want to know more?

Video of latest research

Professor Guy Brown explains the latest research from the lab on how excessive microglial phagocytosis contributes to neurodegeneration. Click on the image below for a 45 min webinar.